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Classes

CHEM 265 Biochemistry I • 5 Cr.

Department

Division

Description:

The first in a two-quarter sequence for science majors and for students interested in careers in pharmacy, dentistry, medicine, veterinary medicine and medical technology. Topics include protein structure and function; carbohydrates and their metabolism, electron transport processes and some of the major metabolic pathways. Prerequisite: BIOL& 211 and CHEM& 261.

Outcomes:

After completing this class, students should be able to:

INTRODUCTION
  • Explain the scientific theory of the origin of life, define evolution and interpret phylogenetic trees
  • Review thermodynamics, intermolecular forces, the hydrophobic effect, and the properties of water
PROTEIN STRUCTURE AND FUNCTION
  • Draw the structure of amino acids at a given pH and discuss the chemistry of the peptide bond
  • Describe all four levels of protein structure and protein folding
  • Describe and recognize different protein purification, analysis and sequencing strategies
  • Describe the biochemical action of muscles, myofibrils and myosin-actin
ENZYMATIC CATALYSIS, KINETICS, INHIBITION AND CONTROL
  • Define enzyme, substrate, cofactors, allosteric, enzyme catalysis and enzyme inhibition
  • Describe enzymatic activity from an energetic standpoint and explain how enzymes work
  • Perform calculations for enzyme kineticsCARBOHYDRATES
  • Describe the chemical structure of carbohydrates
  • Describe lactose, sucrose, cellulose, and the “glycogens” in terms of structure and function
INTRODUCTION TO METABOLISM
  • Give an overview of metabolism in terms of free energy, nutrition, thermodynamics, and flux
  • Explain the concept of a high-energy compound such as ATP, acetyl-CoA
  • Describe how oxidation-reduction plays a role in metabolism
  • Review and integrate the oxidative and biosynthetic metabolic pathways
  • Describe the role of insulin, glucagon, and catecholamines in coordinating metabolism
GLUCOSE CATABOLISM, GLUCOGEN METABOLISM AND GLUCONEOGENESIS
  • Explain glycolysis in full stepwise detail and discuss its regulation
  • Describe the physiological relevance of the pentose phosphate pathway
  • Discuss the pathway of glycogen metabolism and storage and gluconeogenesis
CITRIC ACID CYCLE
  • Discuss the citric acid cycle, its enzymes and its regulation and the special role of acetyl-CoA
ELECTRON TRANSPORT AND OXIDATIVE PHOSPHORYLATION
  • Describe the electron transport system, proton gradients, and ATP synthesis
  • Explain the overall structure and the basic function and mechanism of ATP synthase
PHOTOSYNTHESIS
  • Describe the structure of chloroplasts and the sequence of photosynthesis for cyanobacteria and plants

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Bellevue College
3000 Landerholm Circle SE Bellevue, WA 98007-6484 U.S.A.
Work: (425) 564-1000