CHEM& 263 Organic Chemistry III • 6 Cr.
Third in a three-course sequence. Continues the lecture and lab component of CHEM& 261 and CHEM& 262. Topics include functional groups and biologically important compounds. Format includes laboratory work. Prerequisite: CHEM& 262.
After completing this class, students should be able to:
- Aldehydes and Ketones
- Name and list typical properties of ordinary aldehydes and ketones
- Devise synthetic pathways to produce aldehydes and ketones
- List the differences in terms of reactivity between aldehydes and ketones
- Predict basic reactions of aldehydes, ketones, and alpha-carbons
- Write the mechanism for basic carbonyl reactions.
- Carboxylic Acids and Derivatives
- Name and list minimal properties of carboxylic acids, acid chlorides, acid anhydrides, esters, amides, and nitriles; list the relative reactivity of each
- Devise synthetic pathways between derivatives and from other families.
- Predict basic reactions of derivatives.
- Write the mechanism for all derivative-to-derivative reactions
- Explain the acidity of alpha carbons
- Predict the classic dicarbonyl reactions
- Name and list typical properties of amines, including diazonium salts
- Devise synthetic pathways to produce both aliphatic and aromatic amines
- Predict basic amine reactions
- Write the mechanisms of the Hoffman and Curtius rearrangements
- Lipids and Amino Acids
- Identify the major lipid families, giving properties of each
- Identify isoprene units in typical terpenes and explain the mechanism of soap
- Show the differences between cationic, anionic, and zwitterionic forms of amino acids, and the implications for gel electrophoresis
- Proteins and Nucleic Acids
- Explain transcription and replication, and how it relates to mutation.
- Draw all possible DNA and RNA base pairs, including the phosphate backbone.
- Explain the four levels of protein structure, and the intermolecular forces that determine them. Also explain denaturing, induced fit, and chaperoning.
- Show how proteins are sequenced, and our current limitations