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CHEM 265 Biochemistry I • 5 Cr.




The first in a two-quarter sequence for science majors and for students interested in careers in pharmacy, dentistry, medicine, veterinary medicine and medical technology. Topics include protein structure and function; carbohydrates and their metabolism, electron transport processes and some of the major metabolic pathways. Prerequisite: BIOL& 211 and CHEM& 261.


After completing this class, students should be able to:

  • Introduction
  • • Explain the scientific theory of the origin of life, define evolution and interpret phylogenetic trees
  • • Review thermodynamics, intermolecular forces, the hydrophobic effect, and the properties of water
  • Protein structure and function
  • • Draw the structure of amino acids at a given pH and discuss the chemistry of the peptide bond
  • • Describe all four levels of protein structure and protein folding
  • • Describe and recognize different protein purification, analysis and sequencing strategies
  • • Describe the biochemical action of muscles, myofibrils and myosin-actin
  • Enzymatic catalysis, kinetics, inhibition and control
  • • Define enzyme, substrate, cofactors, allosteric, enzyme catalysis and enzyme inhibition
  • • Describe enzymatic activity from an energetic standpoint and explain how enzymes work
  • • Perform calculations for enzyme kinetics
  • Carbohydrates
  • • Describe the chemical structure of carbohydrates
  • • Describe lactose, sucrose, cellulose, and the “glycogens” in terms of structure and function
  • Introduction to metabolism
  • • Give an overview of metabolism in terms of free energy, nutrition, thermodynamics, and flux
  • • Explain the concept of a high-energy compound such as ATP, acetyl-CoA
  • • Describe how oxidation-reduction plays a role in metabolism
  • • Review and integrate the oxidative and biosynthetic metabolic pathways
  • • Describe the role of insulin, glucagon, and catecholamines in coordinating metabolism
  • Glucose catabolism, glycogen metabolism and gluconeogenesis
  • • Explain glycolysis in full stepwise detail and discuss its regulation
  • • Describe the physiological relevance of the pentose phosphate pathway
  • • Discuss the pathway of glycogen metabolism and storage and gluconeogenesis
  • Citric acid cycle
  • • Discuss the citric acid cycle, its enzymes and its regulation and the special role of acetyl-CoA
  • Electron transport and oxidative phosphorylation
  • • Describe the electron transport system, proton gradients, and ATP synthesis
  • • Explain the overall structure and the basic function and mechanism of ATP synthase
  • Photosynthesis
  • • Describe the structure of chloroplasts and the sequence of photosynthesis for cyanobacteria and plants



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Bellevue College
3000 Landerholm Circle SE Bellevue, WA 98007-6484 U.S.A.
Work: (425) 564-1000